WormBase ID: WBGene00006545 WormBase description: Is an ortholog of human EOMES (eomesodermin) and TBR1 (T-box brain transcription factor 1). Is predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in embryonic body morphogenesis. Localizes to nucleus. Is expressed in several structures, including Eal; Ear; Epl; Epr; and intestine. Human ortholog(s) of this gene are implicated in adrenocorticotropic hormone deficiency; atrial heart septal defect 4; and dysostosis (multiple). |
Reporter verification: Verified by PCR and sequencing |
Strain name: RW10558 Strain genotype: unc-119 (ed3) III; itIs37 (pie-1p::mCherry::H2B::pie-1 3'UTR + unc-119(+)); stIs10116 (his-72p::his-24::mCherry::let-858 3'UTR + unc-119(+)); stIs10470 (tbx-8::TGF(7G2)::GFP::TY1::3xFLAG) |
Expression pattern: Lineage-specific, Muscle-specific, Transient-expression |
Lineage expression pattern 350 stage   |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): CEH-10, ELT-3, TBX-9, TBX-38, RNT-1, TAB-1, GMEB-1, NHR-23, HLH-1, UNC-39, NHR-12, ELT-1, UNC-120, LIN-26, BAZ-2, UNC-62, MLS-2, HAM-2, CEH-20, LIM-7, NHR-25, TBX-11, M03D4.4 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: CEH-20, LIM-7, CEBP-1, CEH-39, CES-2, DAF-19, ETS-5, LAG-1, MDL-1, NHR-102, REF-1, SWSN-7, TLP-1, ZAG-1, ZTF-6 |
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Targeting: CEH-20, CEBP-1, CEH-39, CES-2, DAF-19, ETS-5, LAG-1, MDL-1, SWSN-7, TLP-1 Targeted by: NA |
