END-1

WormBase ID: WBGene00001310

WormBase description: Is an ortholog of several human genes including GATA1 (GATA binding protein 1); GATA5 (GATA binding protein 5); and ZGLP1 (zinc finger GATA like protein 1). Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific. Is involved in endodermal cell fate specification and positive regulation of transcription by RNA polymerase II. Localizes to nucleus. Is expressed in E; E lineage cell; Ea; and Ep. Human ortholog(s) of this gene are implicated in several diseases, including Down syndrome; congenital heart disease (multiple); and hypoparathyroidism-deafness-renal disease syndrome.

KI information: mNeonGreen knockin at C-terminus

Reporter verification:Verified by comparing expression pattern to the literature (Zhu et al., 1997)

Strain name: SYS549

KI background: JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; end-1 (dev162 [end-1::mNeonGreen]) V

Expression pattern: Lineage-specific, Intestine-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): ELT-7, END-3, PQM-1, MML-1, ELT-2, MDL-1, NHR-232, NHR-102, DVE-1, NHR-12, ODD-2, DPFF-1, TBX-9, PHA-4, ATF-7, CEH-20, TBX-11, CEH-74, SEL-8, NHR-10


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: ELT-2, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: ZIP-8