LSL-1

WormBase ID: WBGene00009937

WormBase description: Is an ortholog of several human genes including ZNF407 (zinc finger protein 407); ZNF507; and ZNF777 (zinc finger protein 777). Is predicted to have nucleic acid binding activity. Human ortholog(s) of this gene are implicated in eye disease (multiple) and transient neonatal diabetes mellitus.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-TATGTATCGTCAACACCAAAGC-3'

Strain name: SYS419

Cross: OP720 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs720 (lsl-1::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Tissue-specific (Muscle and Germline), Transient-expression

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): FKH-4, HND-1, REF-1, PAL-1, HLH-1, UNC-120, CEH-39, HMBX-1


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: ZIP-8