SNAI-1

WormBase ID: WBGene00019299

WormBase description: Is an ortholog of human SNAI1 (snail family transcriptional repressor 1) and SNAI2 (snail family transcriptional repressor 2). Is predicted to have RNA polymerase II regulatory region sequence-specific DNA binding activity. Is expressed in PHAL; PHAR; PHBL; PHBR; and amphid neurons.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-CATCTCAGGACGCATACAGG-3'

Strain name: SYS591

Cross: OP698 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs698 (snai-1::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Muscle-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): SYD-9, HLH-8, LIN-39, EGL-5, HLH-1, UNC-120, CEH-20, M03D4.4, PAL-1, HBL-1, TLP-1, UNC-62, CES-2, CEBP-1, F23B12.7, Y75B8A.6


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: HBL-1, Y75B8A.6, AST-1, DAF-19, ETS-5, K09A11.1, LIM-7, NHR-102

Targeted by: HLH-1, UNC-120, UNC-62, HAM-2, RNT-1, UNC-55, PAG-3, UNC-130

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: HBL-1, Y75B8A.6, DAF-19, ETS-5

Targeted by: HLH-1, UNC-120, UNC-62, HAM-2, RNT-1, UNC-55, PAG-3, UNC-130