POP-1

WormBase ID: WBGene00004077

WormBase description: Is an ortholog of human LEF1 (lymphoid enhancer binding factor 1) and TCF7 (transcription factor 7). Exhibits several functions, including RNA polymerase II transcription factor binding activity; beta-catenin binding activity; and enzyme binding activity. Is involved in several processes, including mesodermal cell fate commitment; mitochondrial unfolded protein response; and regulation of transcription, DNA-templated. Localizes to cytoplasm and nucleus. Is expressed in several structures, including ABplpapaaa; ABprpapaaa; oocyte; somatic nervous system; and vulva. Human ortholog(s) of this gene are implicated in type 2 diabetes mellitus.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-CAAAGGCAAACGCTGGAATT-3'

Strain name: SYS88

Cross: OP560 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs560 (pop-1::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Anterior-biased

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: DAF-19, DMD-5, ETS-5, K09A11.1, LIM-7, NHR-102, UNC-62

Targeted by: ALY-1, BCL-11, CEH-19, CEH-31, CEH-36, CEH-39, CEH-43, CEH-83, CND-1, COG-1, ELT-1, ELT-2, ETS-7, HAM-2, HLH-1, HLH-8, HMBX-1, HMG-4, LIN-32, LSY-2, M03D4.4, MEC-3, MEP-1, MLS-2, NFYA-1, NHR-232, PHA-4, PROS-1, REF-2, RNT-1, SEM-2, SPTF-1, SYD-9, TBX-2, UNC-42, UNC-62, ZIP-8, ZTF-11, BLMP-1, CEH-82, CEH-90, DPL-1, DSC-1, EFL-1, EGL-13, FKH-4, FKH-8, IRX-1, SWSN-7, UNC-86

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: DAF-19, DMD-5, ETS-5, UNC-62

Targeted by: ALY-1, BCL-11, CEH-19, CEH-31, CEH-36, CEH-39, CEH-43, CEH-83, CND-1, COG-1, ELT-1, ELT-2, ETS-7, HAM-2, HLH-1, HLH-8, HMBX-1, HMG-4, LSY-2, M03D4.4, MEC-3, MEP-1, MLS-2, NFYA-1, NHR-232, PHA-4, PROS-1, REF-2, RNT-1, SEM-2, SPTF-1, SYD-9, TBX-2, UNC-42, UNC-62, ZIP-8, ZTF-11, BLMP-1, CEH-82, CEH-90, DPL-1, DSC-1, EFL-1, EGL-13, FKH-4, FKH-8, IRX-1, SWSN-7, UNC-86