TAG-68

WormBase ID: WBGene00006445

WormBase description: Is an ortholog of human SMAD6 (SMAD family member 6) and SMAD7 (SMAD family member 7). Is predicted to have DNA binding activity. Is expressed in head neurons; intestine; and ventral nerve cord. Human ortholog(s) of this gene are implicated in aortic valve disease 2.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-ACTCGCCCATTATTTCTATC-3'

Strain name: SYS556

Cross: OP447 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs447 (tag-68::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Expressed after bean stage

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: CEH-18, CEH-31, HLH-8, MEP-1, NFYA-1, REF-2, RNT-1, TBX-2, UNC-120, UNC-42, UNC-55, UNC-62

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: UNC-55, UNC-62