CEH-24

WormBase ID: WBGene00000447

WormBase description: Is an ortholog of human NKX2-1 (NK2 homeobox 1) and NKX2-4 (NK2 homeobox 4). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Is expressed in head muscle; intestine; neurons; non-striated muscle; and ventral nerve cord. Human ortholog(s) of this gene are implicated in double outlet right ventricle and spastic ataxia 8.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GCAAGCGTCAGGAGAAAGAA-3'

Strain name: SYS118

Cross: OP157 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs157 (ceh-24::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Not expressed

Lineage expression pattern

350 stage


600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: DMD-5, ETS-5, K09A11.1, LIM-7, NHR-102

Targeted by: CEH-83, UNC-42

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: DMD-5, ETS-5

Targeted by: CEH-83, UNC-42