SMA-2

WormBase ID: WBGene00004856

WormBase description: Is an ortholog of human SMAD9 (SMAD family member 9). Is predicted to have DNA binding activity and metal ion binding activity. Is involved in several processes, including nematode male tail tip morphogenesis; positive regulation of growth; and positive regulation of nematode male tail tip morphogenesis. Is expressed in head. Human ortholog(s) of this gene are implicated in Loeys-Dietz syndrome 3 and primary pulmonary hypertension.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-ATTCGACGCCTCATTTGATC-3'

Strain name: SYS602

Cross: OP653 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs653 (sma-2::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Expressed after bean stage

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: BCL-11, CEH-18, DVE-1, ELT-1, ELT-2, PHA-4, PQM-1, TBX-2

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: BCL-11, CEH-18, DVE-1, ELT-1, PHA-4, PQM-1, TBX-2