Summary

Gene name
adsl-1
Sequence name
R06C7.5
Gene ID
WBGene00011064
Gene type
Protein Coding
RNAi library location
I-3H05
Gene information
Is an ortholog of human ADSL (adenylosuccinate lyase). Is predicted to have (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Human ortholog(s) of this gene are implicated in adenylosuccinase lyase deficiency.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
ADSL-1_emb1 189 Global proliferation rate changed Global proliferation rate changed 13 15 210
ADSL-1_emb2 191 Global proliferation rate changed Global proliferation rate changed 52 65 371
ADSL-1_emb3 187 Global proliferation rate changed Global proliferation rate changed 87 60 356
With cellular defects Yes No No Yes Yes Yes

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal