Summary

Gene name
aph-2
Sequence name
ZC434.6
Gene ID
WBGene00000148
Gene type
Protein Coding
RNAi library location
I-5M17
Gene information
Is an ortholog of human NCSTN (nicastrin). Is predicted to have endopeptidase activity. Is involved in several processes, including Notch signaling pathway\; cell fate commitment involved in pattern specification\; and embryonic morphogenesis. Localizes to the plasma membrane. Is expressed in the oocyte. Human ortholog(s) of this gene are implicated in hidradenitis suppurativa.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
APH-2_emb1 0 0 0 0 1 0
APH-2_emb2 0 0 0 1 0 0
APH-2_emb3 0 0 0 2 0 0
With cellular defects No No No No No No

Cell Proliferation

Proliferation speed

Cell cycle length

No defects

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

CND-1 expression

No defects

Morphogenesis

Division angle (A-P)

No defects

Relative cell position

No defects