Summary

Gene name
aspm-1
Sequence name
C45G3.1
Gene ID
WBGene00008107
Gene type
Protein Coding
RNAi library location
I-4F17
Gene information
Is an ortholog of human ASPM (abnormal spindle microtubule assembly). Exhibits calmodulin binding activity and protein domain specific binding activity. Is involved in establishment of meiotic spindle orientation\; meiotic spindle organization\; and regulation of protein localization. Localizes to the spindle midzone and spindle pole. Is used to study microcephaly. Human ortholog(s) of this gene are implicated in primary autosomal recessive microcephaly 5.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
ASPM-1_emb1 0 1 0 1 0 0
ASPM-1_emb2 0 0 0 0 6 2
ASPM-1_emb3 79 Global proliferation rate changed Global proliferation rate changed 18 29 245
ASPM-1_emb4 205 Global proliferation rate changed Global proliferation rate changed 1 3 1
ASPM-1_emb5 62 9 4 15 14 122
ASPM-1_emb6 8 4 5 6 2 3
With cellular defects Yes Yes Yes Yes Yes Yes

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

Abnormal division asynchrony
Not analyzed
Normal

Division asymmetry

Larger division asymmetry
Smaller division asymmetry
Not analyzed
Normal

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal