Summary

Gene name
bub-1
Sequence name
R06C7.8
Gene ID
WBGene00000275
Gene type
Protein Coding
RNAi library location
I-3H11
Gene information
Is an ortholog of human BUB1 (BUB1 mitotic checkpoint serine\/threonine kinase). Exhibits kinetochore binding activity. Is involved in several processes, including cell division\; embryonic morphogenesis\; and meiotic nuclear division. Localizes to the kinetochore. Colocalizes with the chromosome. Is expressed in the seam cell. Human ortholog(s) of this gene are implicated in mosaic variegated aneuploidy syndrome 1.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
BUB-1_emb1 2 1 16 1 0 3
BUB-1_emb2 0 10 4 2 0 0
BUB-1_emb3 311 Global proliferation rate changed Global proliferation rate changed 1 0 11
BUB-1_emb4 341 Global proliferation rate changed Global proliferation rate changed 1 0 1
BUB-1_emb5 342 Global proliferation rate changed Global proliferation rate changed 1 2 30
BUB-1_emb6 2 6 13 0 0 2
With cellular defects Yes Yes Yes No No Yes

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

Abnormal division asynchrony
Not analyzed
Normal

Division asymmetry

Larger division asymmetry
Smaller division asymmetry
Not analyzed
Normal

Tissue Marker Expression (CND-1)

CND-1 expression

No defects

Morphogenesis

Division angle (A-P)

No defects

Relative cell position

Abnormal cell position
Not analyzed
Normal