Summary

Gene name
gsk-3
Sequence name
Y18D10A.5
Gene ID
WBGene00001746
Gene type
Protein Coding
RNAi library location
I-6D13
Gene information
Is an ortholog of human GSK3B (glycogen synthase kinase 3 beta). Exhibits protein serine\/threonine kinase activity. Is involved in several processes, including Wnt signaling pathway, regulating spindle positioning\; engulfment of apoptotic cell\; and establishment of mitotic spindle orientation.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
GSK-3_emb1 239 Global proliferation rate changed Global proliferation rate changed 54 91 662
GSK-3_emb2 236 Global proliferation rate changed Global proliferation rate changed 61 109 665
GSK-3_emb3 281 Global proliferation rate changed Global proliferation rate changed 50 81 655
With cellular defects Yes No No Yes Yes Yes

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal