Summary

Gene name
hlh-2
Sequence name
M05B5.5a
Gene ID
WBGene00001949
Gene type
Protein Coding
RNAi library location
I-9G10
Gene information
Is an ortholog of human TCF12 (transcription factor 12)\; TCF3 (transcription factor 3)\; and TCF4 (transcription factor 4). Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific\; bHLH transcription factor binding activity\; and protein dimerization activity. Contributes to RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in several processes, including animal organ development\; body morphogenesis\; and generation of neurons. Localizes to the RNA polymerase II transcription factor complex and cytoplasm. Is expressed in several tissues, including the Z1.ppx\/Z4.aax\; the alimentary system\; the nervous system\; the ray precursor cell\; and the reproductive system. Human ortholog(s) of this gene are implicated in craniosynostosis.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
HLH-2_emb1 351 Global proliferation rate changed Global proliferation rate changed 40 149 693
HLH-2_emb2 353 Global proliferation rate changed Global proliferation rate changed 7 20 567
With cellular defects Yes No No Yes Yes Yes

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal