Summary

Gene name
hmp-2
Sequence name
K05C4.6
Gene ID
WBGene00001979
Gene type
Protein Coding
RNAi library location
I-7E20
Gene information
Is an ortholog of human CTNNB1 (catenin beta 1) and JUP (junction plakoglobin). Exhibits several functions, including alpha-catenin binding activity\; cadherin binding activity\; and protein domain specific binding activity. Is involved in several processes, including canonical Wnt signaling pathway\; embryo development\; and embryonic morphogenesis. Localizes to the catenin complex\; cell-cell adherens junction\; and nucleus. Human ortholog(s) of this gene are implicated in several diseases, including arrhythmogenic right ventricular dysplasia 12\; autosomal dominant non-syndromic intellectual disability 19\; and endocrine gland cancer (multiple).

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A/P)		 Cell
position		 Phenotype
detection
HMP-2_emb1 6 64 1 1 4 5
HMP-2_emb2 0 0 0 0 0 0
HMP-2_emb3 13 115 4 0 20 45
HMP-2_emb4 351 Global proliferation rate changed Global proliferation rate changed 3 7 175
HMP-2_emb5 312 Global proliferation rate changed Global proliferation rate changed 0 11 151
HMP-2_emb6 353 Global proliferation rate changed Global proliferation rate changed 3 0 0
HMP-2_emb7 348 Global proliferation rate changed Global proliferation rate changed 0 0 0
HMP-2_emb8 350 Global proliferation rate changed Global proliferation rate changed 0 0 0
With cellular defects Yes Yes Yes Yes Yes Yes

Early embryonic arrest

Arrest embryo: HMP-2_emb9

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

Abnormal division asynchrony
Not analyzed
Normal

Division asymmetry(A/P)

Larger division asymmetry
Smaller division asymmetry
Not analyzed
Normal

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle(A/P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal