Summary

Gene name
lars-2
Sequence name
ZK524.3a
Gene ID
WBGene00003074
Gene type
Protein Coding
RNAi library location
I-9A19
Gene information
Is an ortholog of human LARS2 (leucyl-tRNA synthetase 2, mitochondrial). Is predicted to have leucine-tRNA ligase activity. Is expressed in the body wall musculature\; the intestine\; and the nervous system. Is used to study Perrault syndrome. Human ortholog(s) of this gene are implicated in Perrault syndrome.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
LARS-2_emb1 353 Global proliferation rate changed Global proliferation rate changed 16 4 1
LARS-2_emb2 353 Global proliferation rate changed Global proliferation rate changed 11 2 0
LARS-2_emb3 351 Global proliferation rate changed Global proliferation rate changed 15 1 0
LARS-2_emb4 265 Global proliferation rate changed Global proliferation rate changed 1 0 0
LARS-2_emb5 320 Global proliferation rate changed Global proliferation rate changed 0 0 0
LARS-2_emb6 301 Global proliferation rate changed Global proliferation rate changed 1 0 0
With cellular defects Yes No No Yes Yes No

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

No defects