Summary

Gene name
let-526
Sequence name
F48C1.4
Gene ID
WBGene00002717
Gene type
Protein Coding
RNAi library location
I-2I18
Gene information
Is an ortholog of human ARID1A (AT-rich interaction domain 1A) and ARID1B (AT-rich interaction domain 1B). Is predicted to have DNA binding activity. Is involved in nematode larval development and positive regulation of transcription by RNA polymerase II. Localizes to the nucleus. Is expressed in several tissues, including the body wall musculature\; the excretory cell\; the hypodermis\; the pharynx\; and the reproductive system. Human ortholog(s) of this gene are implicated in Coffin-Siris syndrome 2.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
LET-526_emb1 57 19 34 30 26 405
LET-526_emb2 70 42 36 32 33 409
With cellular defects Yes Yes Yes Yes Yes Yes

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

Abnormal division asynchrony
Not analyzed
Normal

Division asymmetry

Larger division asymmetry
Smaller division asymmetry
Not analyzed
Normal

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal