Summary

Gene name
lin-35
Sequence name
C32F10.2
Gene ID
WBGene00003020
Gene type
Protein Coding
RNAi library location
I-2N15
Gene information
Is an ortholog of human RBL1 (RB transcriptional corepressor like 1) and RBL2 (RB transcriptional corepressor like 2). Exhibits protein C-terminus binding activity. Is involved in several processes, including animal organ development\; embryo development\; and negative regulation of cell cycle. Localizes to the nucleus. Is expressed in several tissues, including the head and the tail. Human ortholog(s) of this gene are implicated in several diseases, including lung small cell carcinoma\; osteosarcoma\; and retinoblastoma.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
LIN-35_emb1 34 0 3 0 1 0
LIN-35_emb2 0 0 0 2 0 0
With cellular defects No No Yes No No No

Cell Proliferation

Proliferation speed

Cell cycle length

No defects

Division asynchrony

No defects

Division asymmetry

Larger division asymmetry
Smaller division asymmetry
Not analyzed
Normal

Tissue Marker Expression (CND-1)

CND-1 expression

No defects

Morphogenesis

Division angle (A-P)

No defects

Relative cell position

No defects