Summary

Gene name
lin-53
Sequence name
K07A1.12
Gene ID
WBGene00003036
Gene type
Protein Coding
RNAi library location
I-4D14
Gene information
Is an ortholog of human RBBP4 (RB binding protein 4, chromatin remodeling factor) and RBBP7 (RB binding protein 7, chromatin remodeling factor). Exhibits histone deacetylase binding activity. Is involved in several processes, including animal organ development\; cell fate specification\; and embryo development. Localizes to the DRM complex. Is expressed in several tissues, including the head\; the hypodermis\; and the tail.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
LIN-53_emb1 94 Global proliferation rate changed Global proliferation rate changed 5 22 117
LIN-53_emb2 75 7 22 3 28 150
LIN-53_emb3 95 Global proliferation rate changed Global proliferation rate changed 23 18 128
With cellular defects Yes Yes Yes Yes Yes Yes

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

Abnormal division asynchrony
Not analyzed
Normal

Division asymmetry

Larger division asymmetry
Smaller division asymmetry
Not analyzed
Normal

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal