Summary

Gene name
lmn-1
Sequence name
DY3.2
Gene ID
WBGene00003052
Gene type
Protein Coding
RNAi library location
I-4G24
Gene information
Is an ortholog of human LMNA (lamin A\/C). Exhibits histone binding activity\; identical protein binding activity\; and structural molecule activity. Is involved in several processes, including determination of adult lifespan\; embryo development\; and germ cell development. Localizes to the nuclear envelope and nuclear periphery. Is expressed widely. Is used to study Emery-Dreifuss muscular dystrophy\; congenital muscular dystrophy\; and progeria.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A/P)		 Cell
position		 Phenotype
detection
LMN-1_emb1 196 Global proliferation rate changed Global proliferation rate changed 46 66 573
LMN-1_emb2 187 20 67 56 62 423
With cellular defects Yes Yes Yes Yes Yes Yes

Early embryonic arrest

Arrest embryo: LMN-1_emb3

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

Abnormal division asynchrony
Not analyzed
Normal

Division asymmetry(A/P)

Larger division asymmetry
Smaller division asymmetry
Not analyzed
Normal

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle(A/P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal