Summary

Gene name
lrk-1
Sequence name
T27C10.5
Gene ID
WBGene00003068
Gene type
Protein Coding
RNAi library location
I-5B19
Gene information
Is an ortholog of human LRRK1 (leucine rich repeat kinase 1). Is predicted to have metal ion binding activity\; nucleoside phosphate binding activity\; and protein serine\/threonine kinase activity. Is involved in several processes, including axon extension involved in axon guidance\; cellular protein localization\; and negative regulation of neuron death. Localizes to the Golgi apparatus and neuronal cell body. Is expressed in the nervous system\; the pharynx\; and the reproductive system. Is used to study Parkinson's disease. Human ortholog(s) of this gene are implicated in autosomal dominant Parkinson's disease 8.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
LRK-1_emb1 0 0 0 2 0 0
LRK-1_emb2 0 0 0 0 0 0
LRK-1_emb3 0 0 0 0 0 0
With cellular defects No No No No No No

Cell Proliferation

Proliferation speed

Cell cycle length

No defects

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

CND-1 expression

No defects

Morphogenesis

Division angle (A-P)

No defects

Relative cell position

No defects