Summary

Gene name
msh-2
Sequence name
H26D21.2
Gene ID
WBGene00003418
Gene type
Protein Coding
RNAi library location
I-1F17
Gene information
Is an ortholog of human MSH2 (mutS homolog 2). Is predicted to contribute to four-way junction DNA binding activity\; guanine\/thymine mispair binding activity\; and single thymine insertion binding activity. Is involved in DNA metabolic process\; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator\; and reproduction. Human ortholog(s) of this gene are implicated in Lynch syndrome 1 and Muir-Torre syndrome.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
MSH-2_emb1 0 0 0 0 2 2
MSH-2_emb2 0 0 0 0 0 0
MSH-2_emb3 0 0 0 0 0 0
With cellular defects No No No No No No

Cell Proliferation

Proliferation speed

Cell cycle length

No defects

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

CND-1 expression

No defects

Morphogenesis

Division angle (A-P)

No defects

Relative cell position

No defects