Summary

Gene name
mtm-1
Sequence name
Y110A7A.p
Gene ID
WBGene00003475
Gene type
Protein Coding
RNAi library location
I-2E18
Gene information
Is an ortholog of human MTMR2 (myotubularin related protein 2). Exhibits phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity\; phosphatidylinositol-3-phosphatase activity\; and phosphatidylinositol-4,5-bisphosphate binding activity. Is involved in negative regulation of engulfment of apoptotic cell and phospholipid dephosphorylation. Localizes to the apical cortex\; cytosol\; and plasma membrane. Is expressed in several tissues, including the alimentary system\; the coelomocyte\; the hypodermis\; the nervous system\; and the reproductive system. Is used to study centronuclear myopathy. Human ortholog(s) of this gene are implicated in Charcot-Marie-Tooth disease type 4B1 and centronuclear myopathy.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
MTM-1_emb1 0 1 0 0 1 0
MTM-1_emb2 0 0 0 0 0 0
MTM-1_emb3 0 0 0 0 0 0
With cellular defects No No No No No No

Cell Proliferation

Proliferation speed

Cell cycle length

No defects

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

CND-1 expression

No defects

Morphogenesis

Division angle (A-P)

No defects

Relative cell position

No defects