Summary

Gene name
ned-8
Sequence name
F45H11.2
Gene ID
WBGene00003587
Gene type
Protein Coding
RNAi library location
I-5O03
Gene information
Is an ortholog of human NEDD8 (NEDD8 ubiquitin like modifier). Is predicted to have protein tag and ubiquitin protein ligase binding activity. Is involved in negative regulation of DNA damage response, signal transduction by p53 class mediator\; negative regulation of gene expression\; and regulation of programmed cell death. Localizes to the cytoplasm and nucleus.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A/P)		 Cell
position		 Phenotype
detection
NED-8_emb1 173 Global proliferation rate changed Global proliferation rate changed 56 105 661
With cellular defects Yes No No Yes Yes Yes

Early embryonic arrest

Arrest embryo: NED-8_emb2, NED-8_emb3, NED-8_emb4

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

No defects

Division asymmetry(A/P)

No defects

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle(A/P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal