Gene name

nhr-49

Sequence name

K10C3.6

Gene ID

WBGene00003639

Gene type

Protein Coding

RNAi library location

I-4N14

Gene information

Is an ortholog of human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). Is predicted to have several functions, including DNA-binding transcription factor activity\; sequence-specific DNA binding activity\; and steroid hormone receptor activity. Is involved in determination of adult lifespan\; positive regulation of transcription from RNA polymerase II promoter in response to stress\; and regulation of fatty acid metabolic process. Localizes to the cytoplasm and nucleus. Is expressed in the hypodermis\; the intestinal cell\; the muscle cell\; and the nervous system. Is used to study obesity. Human ortholog(s) of this gene are implicated in maturity-onset diabetes of the young type 1 and type 2 diabetes mellitus.