Summary

Gene name
pole-1
Sequence name
F33H2.5
Gene ID
WBGene00009368
Gene type
Protein Coding
RNAi library location
I-7M18
Gene information
Is an ortholog of human POLE (DNA polymerase epsilon, catalytic subunit). Is predicted to have DNA binding activity\; DNA-directed DNA polymerase activity\; and single-stranded DNA 3'-5' exodeoxyribonuclease activity.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
POLE-1_emb1 167 Global proliferation rate changed Global proliferation rate changed 39 55 330
POLE-1_emb2 103 Global proliferation rate changed Global proliferation rate changed 10 42 201
POLE-1_emb3 117 Global proliferation rate changed Global proliferation rate changed 10 38 237
POLE-1_emb4 184 Global proliferation rate changed Global proliferation rate changed 28 30 357
POLE-1_emb5 178 Global proliferation rate changed Global proliferation rate changed 27 35 322
With cellular defects Yes No No Yes Yes Yes

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal