Summary

Gene name
pop-1
Sequence name
W03D8.4
Gene ID
WBGene00004077
Gene type
Protein Coding
RNAi library location
I-1K04
Gene information
Is an ortholog of human LEF1 (lymphoid enhancer binding factor 1)\; TCF7 (transcription factor 7)\; and TCF7L2 (transcription factor 7 like 2). Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific\; RNA polymerase II regulatory region sequence-specific DNA binding activity\; and enzyme binding activity. Is involved in several processes, including asymmetric cell division\; formation of primary germ layer\; and regulation of cellular biosynthetic process. Localizes to the cytoplasm and nucleus. Is expressed in several tissues, including the Q cell\; the alimentary system\; the epithelial system\; the nervous system\; and the reproductive system. Human ortholog(s) of this gene are implicated in type 2 diabetes mellitus.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
POP-1_emb1 32 64 28 37 64 486
POP-1_emb2 34 66 39 45 65 482
POP-1_emb3 54 65 39 32 67 499
With cellular defects Yes Yes Yes Yes Yes Yes

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

Abnormal division asynchrony
Not analyzed
Normal

Division asymmetry

Larger division asymmetry
Smaller division asymmetry
Not analyzed
Normal

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal