Summary

Gene name
smn-1
Sequence name
C41G7.1
Gene ID
WBGene00004887
Gene type
Protein Coding
RNAi library location
I-4P11
Gene information
Is an ortholog of human SMN2 (survival of motor neuron 2, centromeric). Exhibits protein self-association. Is involved in several processes, including determination of adult lifespan\; embryo development\; and germ cell development. Localizes to the nucleus. Is expressed in several tissues, including the hypodermis\; the intestine\; and the muscular system. Is used to study spinal muscular atrophy. Human ortholog(s) of this gene are implicated in several diseases, including survival motor neuron spinal muscular atrophy (multiple).

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
SMN-1_emb1 315 Global proliferation rate changed Global proliferation rate changed 9 3 1
SMN-1_emb2 352 Global proliferation rate changed Global proliferation rate changed 20 5 7
SMN-1_emb3 261 Global proliferation rate changed Global proliferation rate changed 8 5 113
With cellular defects Yes No No Yes Yes Yes

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal