Summary

Gene name
spg-7
Sequence name
Y47G6A_247.f
Gene ID
WBGene00004978
Gene type
Protein Coding
RNAi library location
I-7P23
Gene information
Is an ortholog of human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2). Is predicted to have metalloendopeptidase activity. Is involved in several processes, including cellular protein-containing complex assembly\; defense response to Gram-negative bacterium\; and regulation of gene expression. Is expressed in the germ line. Human ortholog(s) of this gene are implicated in spastic ataxia 5 and spinocerebellar ataxia type 28.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A/P)		 Cell
position		 Phenotype
detection
SPG-7_emb1 346 Global proliferation rate changed Global proliferation rate changed 1 0 0
SPG-7_emb2 217 Global proliferation rate changed Global proliferation rate changed 8 0 1
SPG-7_emb3 181 Global proliferation rate changed Global proliferation rate changed 4 0 0
SPG-7_emb4 175 Global proliferation rate changed Global proliferation rate changed 13 0 0
With cellular defects Yes No No Yes No No

Early embryonic arrest

Arrest embryo: SPG-7_emb5, SPG-7_emb6

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

No defects

Division asymmetry(A/P)

No defects

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle(A/P)

No defects

Relative cell position

No defects