Summary

Gene name
sup-17
Sequence name
DY3.7
Gene ID
WBGene00006324
Gene type
Protein Coding
RNAi library location
I-4I10
Gene information
Is an ortholog of human ADAM10 (ADAM metallopeptidase domain 10). Is predicted to have metallopeptidase activity. Is involved in several processes, including Notch signaling pathway\; cell fate specification\; and embryo development. Localizes to the cytoplasmic vesicle membrane and plasma membrane. Is expressed in the M lineage cell\; the hypodermis\; the intestinal cell\; the spermatheca\; and the vulva. Human ortholog(s) of this gene are implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
SUP-17_emb1 0 0 0 0 0 0
SUP-17_emb2 0 0 0 2 2 5
SUP-17_emb3 0 0 0 0 1 0
With cellular defects No No No No No Yes

Cell Proliferation

Proliferation speed

Cell cycle length

No defects

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

CND-1 expression

No defects

Morphogenesis

Division angle (A-P)

No defects

Relative cell position

Abnormal cell position
Not analyzed
Normal