Summary

Gene name
tlf-1
Sequence name
F39H11.2
Gene ID
WBGene00006577
Gene type
Protein Coding
RNAi library location
I-4E14
Gene information
Is an ortholog of human TBPL1 (TATA-box binding protein like 1). Is predicted to have DNA-binding transcription factor activity\; nucleic acid binding activity\; and transcription factor binding activity. Is involved in embryo development\; negative regulation of transcription by RNA polymerase II\; and positive regulation of cellular metabolic process. Localizes to the nucleus. Is expressed widely.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
TLF-1_emb1 283 Global proliferation rate changed Global proliferation rate changed 55 93 595
TLF-1_emb2 285 Global proliferation rate changed Global proliferation rate changed 58 149 641
TLF-1_emb3 279 Global proliferation rate changed Global proliferation rate changed 60 123 630
With cellular defects Yes No No Yes Yes Yes

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal