Summary

Gene name
top-1
Sequence name
M01E5.5
Gene ID
WBGene00006595
Gene type
Protein Coding
RNAi library location
I-6B20
Gene information
Is an ortholog of human TOP1 (DNA topoisomerase I) and TOP1MT (DNA topoisomerase I mitochondrial). Exhibits DNA topoisomerase type I activity. Localizes to the nucleolus and spindle pole centrosome. Is expressed in the excretory cell\; the intestine\; the nervous system\; and the reproductive system.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
TOP-1_emb1 4 0 0 3 3 0
TOP-1_emb2 0 0 3 0 1 1
TOP-1_emb3 0 0 0 0 3 0
With cellular defects No No Yes Yes Yes No

Cell Proliferation

Proliferation speed

Cell cycle length

No defects

Division asynchrony

No defects

Division asymmetry

Larger division asymmetry
Smaller division asymmetry
Not analyzed
Normal

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

No defects