Summary

Gene name
ubc-12
Sequence name
R09B3.4
Gene ID
WBGene00006707
Gene type
Protein Coding
RNAi library location
I-5P22
Gene information
Is an ortholog of human UBE2F (ubiquitin conjugating enzyme E2 F (putative)). Exhibits NEDD8 transferase activity. Is involved in negative regulation of DNA damage response, signal transduction by p53 class mediator and protein neddylation. Is expressed in the hyp10.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A/P)		 Cell
position		 Phenotype
detection
UBC-12_emb1 338 Global proliferation rate changed Global proliferation rate changed 2 12 71
UBC-12_emb2 296 Global proliferation rate changed Global proliferation rate changed 52 57 618
UBC-12_emb3 286 Global proliferation rate changed Global proliferation rate changed 26 91 615
With cellular defects Yes No No Yes Yes Yes

Early embryonic arrest

Arrest embryo: UBC-12_emb4, UBC-12_emb5, UBC-12_emb6

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

No defects

Division asymmetry(A/P)

No defects

Tissue Marker Expression (CND-1)

Wild type tissue marker expression

Stable expression
Stable non-expression or partial expression

CND-1 expression

Gain of CND-1 expression
Loss of CND-1 expression
Normal

Morphogenesis

Division angle(A/P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

Abnormal cell position
Not analyzed
Normal