Summary

Gene name
unc-40
Sequence name
T19B4.6
Gene ID
WBGene00006776
Gene type
Protein Coding
RNAi library location
I-2J21
Gene information
Is an ortholog of human DCC (DCC netrin 1 receptor) and NEO1 (neogenin 1). Exhibits protein domain specific binding activity. Is involved in several processes, including cell surface receptor signaling pathway\; gonad morphogenesis\; and nervous system development. Localizes to the cell projection membrane\; integral component of plasma membrane\; and receptor complex. Is expressed in several tissues, including the ABalaa\; the Q cell\; the nervous system\; the reproductive system\; and the ventral cord blast cell. Human ortholog(s) of this gene are implicated in colorectal cancer and esophageal cancer.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
UNC-40_emb1 0 0 0 0 5 0
UNC-40_emb2 0 0 0 0 0 0
UNC-40_emb3 0 0 0 0 0 0
With cellular defects No No No No Yes No

Cell Proliferation

Proliferation speed

Cell cycle length

No defects

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

CND-1 expression

No defects

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

No defects