Summary

Gene name
wwp-1
Sequence name
Y65B4B_10.a
Gene ID
WBGene00007009
Gene type
Protein Coding
RNAi library location
I-8A05
Gene information
Is an ortholog of human ITCH (itchy E3 ubiquitin protein ligase) and WWP1 (WW domain containing E3 ubiquitin protein ligase 1). Exhibits ubiquitin conjugating enzyme activity. Is involved in determination of adult lifespan\; protein ubiquitination\; and regulation of protein catabolic process. Localizes to the cytoplasm. Is expressed in GABAergic neurons\; cholinergic neurons\; somatic neurons\; the coelomocyte\; and the vulval muscle.

Lineage tracing results

Phenotype

Cell
cycle		 Division
asynchrony		 Division
asymmetry		 CND-1
expression		 Division
angle
(A-P)		 Cell
position		 Phenotypic
measurement		 Phenotypic
detection
WWP-1_emb1 0 0 0 0 5 2
WWP-1_emb2 60 Global proliferation rate changed Global proliferation rate changed 0 1 0
WWP-1_emb3 0 0 0 1 4 0
With cellular defects Yes No No No Yes No

Cell Proliferation

Proliferation speed

Cell cycle length

Longer cell cycle length
Shorter cell cycle length
Not analyzed
Normal

Division asynchrony

No defects

Division asymmetry

No defects

Tissue Marker Expression (CND-1)

CND-1 expression

No defects

Morphogenesis

Division angle (A-P)

Larger division angle (A-P)
Smaller division angle (A-P)
Not analyzed
Normal

Relative cell position

No defects