FKH-2

WormBase ID: WBGene00001434

WormBase description: Is an ortholog of human FOXG1 (forkhead box G1). Exhibits DNA-binding transcription factor activity. Is involved in several processes, including nematode larval development; neuron differentiation; and non-motile cilium assembly. Localizes to nucleus. Is expressed in several structures, including AWB; Daaa; body wall muscle cell from D lineage; head muscle; and somatic nervous system. Human ortholog(s) of this gene are implicated in Rett syndrome; cataract 34 multiple types; and congenital aphakia.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GCAAACCTCTTCCCATACTTC-3'

Strain name: SYS224

Cross: OP185 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs185 (fkh-2-1::TY1::EGFP::3xFLAG(92C12) + unc-119(+))

Expression pattern: Lineage-specific, Transient-expression

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): EGL-13, LIM-4, CEH-8, UNC-42, DAF-19, TTX-3, SPTF-1, CND-1, ALR-1, CEH-48, HLH-3, CEH-32, HLH-14, UNC-39, TTX-1


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: HLH-1, ZIP-8, ELT-3, RNT-1

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: HLH-1