WormBase ID: WBGene00006775 WormBase description: Is an ortholog of human SIX4 (SIX homeobox 4) and SIX5 (SIX homeobox 5). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Is involved in several processes, including generation of neurons; mesodermal cell migration; and oviposition. Localizes to nucleus. Is expressed in several structures, including RID; amphid neurons; body wall musculature; coelomocyte; and neuroblasts. Is used to study branchiootorenal syndrome and myotonic dystrophy type 1. Human ortholog(s) of this gene are implicated in branchiootorenal syndrome 2. |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS174 Cross: OP186 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs186 (unc-39::TY1::EGFP::3xFLAG(92C12) + unc-119(+)) |
Expression pattern: Lineage-specific, Neuronal-specific |
Lineage expression pattern 350 stage    |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): UNC-30, PAG-3, CEH-8, MBF-1, BED-3, Y73E7A.1, TAB-1, PROS-1, CEH-32, Y56A3A.28, HLH-30, ALR-1, CEH-41, LIN-32, Y48G1C.6, SOX-2, LIM-7, TBX-7, TBX-8, SPTF-1, REF-2, CEH-43, EGL-44, NFI-1, FKH-2, ELT-6, CRH-2 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: LIM-7, CEH-20, DAF-19, ETS-5, MDL-1, NHR-102, SEL-8 Targeted by: LIN-32, SPTF-1, REF-2, ALY-1, DMD-4, MEC-3, CEH-82, FKH-10, FKH-8, PAX-3 |
|
Targeting: CEH-20, DAF-19, ETS-5, MDL-1 Targeted by: NA |
