DMD-4

WormBase ID: WBGene00007776

WormBase description: Is an ortholog of human DMRT3 (doublesex and mab-3 related transcription factor 3). Is predicted to have DNA-binding transcription factor activity; metal ion binding activity; and sequence-specific DNA binding activity. Is expressed in neurons.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-CTCGTGGGATTGATCGGCTAA-3'

Strain name: SYS137

Cross: OP418 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs418 (dmd-4::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Pharynx-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): CEH-60, CEH-22, PHA-2, ODD-2, CEH-51, TBX-7, CEH-34, PHA-4, IRX-1, HMBX-1, TBX-2, EFL-3, CEH-36, LAG-1, Y75B8A.6


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: LAG-1, BCL-11, DAF-12, DAF-19, EGRH-1, ETS-5, GMEB-1, HBL-1, HLH-30, K09A11.1, LIM-7, MEP-1, NHR-102, RCOR-1, SEL-8, UNC-39, UNC-62

Targeted by: PHA-4, CEH-36, ZIP-8, DSC-1

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: LAG-1, BCL-11, DAF-19, ETS-5, GMEB-1, HBL-1, HLH-30, MEP-1, RCOR-1, UNC-62

Targeted by: PHA-4, CEH-36