WormBase ID: WBGene00006796
WormBase description: Is an ortholog of human MEIS1 (Meis homeobox 1) and MEIS2 (Meis homeobox 2). Is predicted to have DNA binding activity. Is involved in mesodermal cell fate specification; muscle cell differentiation; and positive regulation of translation. Localizes to nucleus. Is expressed in several structures, including body wall musculature; neurons; reproductive system; ventral nerve cord; and vulval precursor cell. Is used to study leukemia and restless legs syndrome. |
Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-TTCCAAGTGGCTCCAACAGT-3' |
Strain name: SYS116 Cross: SD1871 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs600 (unc-62::TY1::EGFP::3xFLAG(92C12) + unc-119(+)) |
Expression pattern: Lineage-specific, Muscle-specific, Transient-expression
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Lineage expression pattern
350 stage
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600 stage
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3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships
Based on expression similarity (strong, medium, weak): LIN-22, LIN-39, CEH-60, ELT-3, CEH-40, SNAI-1, RNT-1, CEH-20, GMEB-1, NHR-23, UNC-3, CEH-13, HLH-1, VAB-15, CEH-16, EGL-5, LIN-26, UNC-120, LIN-1, TLP-1, ELT-1, VAB-7, IRX-1, NHR-12, TBX-9, BAZ-2, M03D4.4, PAL-1, HBL-1, NHR-25, TBX-8, CND-1, F23B12.7, CEBP-1, HAM-2, ATF-7
Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)
Targeting: LIN-22, LIN-39, ELT-3, CEH-40, SNAI-1, RNT-1, CEH-20, NHR-23, UNC-3, CEH-13, HLH-1, VAB-15, CEH-16, UNC-120, LIN-1, TLP-1, ELT-1, VAB-7, M03D4.4, PAL-1, HBL-1, NHR-25, TBX-8, CEBP-1, HAM-2, AHR-1, ALY-1, BLMP-1, CEH-18, CEH-34, CEH-38, CEH-39, CEH-43, CEH-44, CFI-1, CRH-2, DAF-12, DAF-3, EFL-1, EGL-18, EGL-44, EGRH-1, ETS-5, FOS-1, HLH-11, HLH-14, HLH-2, HLH-30, LAG-1, LIM-7, MDL-1, MEF-2, MEP-1, MML-1, NGN-1, NHR-10, NHR-102, NHR-35, NHR-49, POP-1, SDZ-38, SEM-4, SKN-1, SPTF-1, SWSN-7, SYD-9, TAG-68, TTX-1, UNC-130, UNC-30, UNC-37, VAB-3, Y75B8A.6, ZAG-1, ZTF-11, ZTF-6
Targeted by: RNT-1, UNC-3, HLH-1, UNC-120, ELT-1, M03D4.4, CND-1, HAM-2, BLMP-1, CEH-14, CEH-18, CEH-2, CEH-31, CEH-34, CEH-36, CEH-39, CEH-6, CEH-83, CHE-1, DMD-4, GMEB-2, HLH-30, HLH-8, HMG-4, LIN-11, LIN-13, LIN-32, LSY-2, MLS-2, NFYA-1, PHA-2, POP-1, REF-2, SEM-2, SPTF-1, SYD-9, TBX-2, UNC-42, UNC-55, ZIP-8, LIN-39, ELT-3, VAB-15, TLP-1, IRX-1, ALY-2, C16A3.4, CEH-8, CEH-82, DPL-1, DSC-1, EFL-1, EGL-13, FKH-4, FOS-1, MDL-1, MEF-2, MEP-1, NHR-85, PAG-3, SWSN-7, UNC-130, UNC-86, ZTF-11 |
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 Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)
Targeting: LIN-39, ELT-3, CEH-40, SNAI-1, CEH-20, NHR-23, CEH-13, HLH-1, VAB-15, CEH-16, UNC-120, TLP-1, ELT-1, CEBP-1, HAM-2, AHR-1, ALY-1, CEH-18, CEH-34, CEH-39, CEH-43, CEH-5, CRH-2, DAF-3, EFL-1, EGL-44, ETS-5, HLH-30, LAG-1, MDL-1, MEF-2, MEP-1, MML-1, NHR-10, NHR-35, NHR-49, POP-1, SEM-4, SKN-1, SWSN-7, SYD-9, TAG-68, UNC-130, UNC-37, ZAG-1
Targeted by: RNT-1, UNC-3, HLH-1, UNC-120, ELT-1, M03D4.4, CND-1, HAM-2, BLMP-1, CEH-14, CEH-18, CEH-2, CEH-31, CEH-34, CEH-36, CEH-6, CEH-83, CHE-1, DMD-4, GMEB-2, HLH-8, HMG-4, LIN-11, LIN-13, LIN-32, LSY-2, MLS-2, NFYA-1, POP-1, REF-2, SEM-2, SPTF-1, SYD-9, TBX-2, UNC-42, UNC-55, ZIP-8, LIN-39, ELT-3, VAB-15, TLP-1, IRX-1, ALY-2, C16A3.4, CEH-8, CEH-82, DPL-1, DSC-1, EFL-1, EGL-13, FKH-4, FOS-1, MDL-1, MEF-2, MEP-1, NHR-85, PAG-3, SWSN-7, UNC-130, UNC-86, ZTF-11
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