CEH-18

WormBase ID: WBGene00000441

WormBase description: Is an ortholog of human POU2F3 (POU class 2 homeobox 3). Is predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific. Is involved in epidermis development; gamete generation; and negative regulation of oocyte maturation. Localizes to nucleus. Is expressed in body wall musculature; gonad; neurons; non-striated muscle; and somatic nervous system.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GGGATGTTGTAAGGGTATGGT-3'

Strain name: SYS177

Cross: OP533 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs533 (ceh-18::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Expressed after bean stage

Lineage expression pattern

350 stage




600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: ATFS-1, ATHP-1, BCL-11, CAMT-1, CEBP-1, CEH-13, CEH-20, CEH-38, CEH-39, CEH-44, CRH-2, DAF-12, DAF-19, DAF-3, DMD-5, EFL-1, EGRH-1, ETS-5, FOS-1, GMEB-1, HBL-1, HLH-1, HLH-11, HLH-30, IRX-1, K09A11.1, LAG-1, LIM-7, LIN-11, LIN-13, LIN-39, LSY-2, MDL-1, MEF-2, MEP-1, MML-1, NHR-10, NHR-102, NHR-35, NHR-49, PHA-4, RCOR-1, RNT-1, SDZ-38, SEM-4, SKN-1, SMA-2, SWSN-7, TAG-68, TBX-2, TLP-1, UNC-37, UNC-62, Y55F3AM.14, ZFH-2, ZTF-6

Targeted by: HLH-1, RNT-1, UNC-120, UNC-42, UNC-62

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: ATFS-1, ATHP-1, BCL-11, CAMT-1, CEBP-1, CEH-13, CEH-20, CEH-39, CEH-44, CEH-5, CRH-2, DAF-19, DMD-5, EFL-1, ETS-5, GMEB-1, HBL-1, HLH-1, HLH-11, HLH-30, IRX-1, K10B3.5, LAG-1, LIN-11, LIN-13, LSY-2, MDL-1, MEF-2, MEP-1, MML-1, NHR-10, NHR-35, NHR-49, PHA-4, RCOR-1, SEM-4, SKN-1, SMA-2, SVH-5, SWSN-7, TBX-2, TLP-1, UNC-37, UNC-62, ZFH-2

Targeted by: UNC-120, UNC-42, UNC-62