LIN-13

WormBase ID: WBGene00003002

WormBase description: Is an ortholog of several human genes including ZNF423 (zinc finger protein 423); ZNF462 (zinc finger protein 462); and ZNF786 (zinc finger protein 786). Is predicted to have RNA polymerase II core promoter sequence-specific DNA binding activity. Is involved in negative regulation of vulval development and reproduction. Localizes to nucleus. Is expressed in several structures, including body wall musculature; hermaphrodite distal tip cell; hypodermal cell; intestine; and neurons. Human ortholog(s) of this gene are implicated in nephronophthisis 14.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GTGGAAATGCAGCGTTGTTA-3'

Strain name: RW10560

Strain genotype: unc-119 (ed3) III; itIs37 (pie-1p::mCherry::H2B::pie-1 3'UTR + unc-119(+)); stIs10116 (his-72p::his-24::mCherry::let-858 3'UTR + unc-119(+)); stIs10452 (lin-13::TGF(6.2B12)::GFP::TY1::3xFLAG)

Expression pattern: Non-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: ALY-1, ATHP-1, CEH-20, CEH-38, CEH-39, CEH-44, DPFF-1, EFL-1, EFL-3, ETS-5, HBL-1, HLH-11, HLH-2, HLH-30, HMG-20, LIM-7, LIN-15B, LSY-2, MDL-1, MEP-1, MML-1, NFYA-1, NHR-102, RCOR-1, SWSN-7, UNC-37, UNC-62, ATFS-1, CAMT-1, CEBP-1, CRH-2, DAF-12, DAF-3, DMD-5, EGRH-1, FOS-1, GMEB-1, HLH-1, LAG-1, MEF-2, NHR-10, NHR-23, NHR-35, NHR-49, NHR-85, SDZ-38, SKN-1, SMA-2, TLP-1, Y55F3AM.14, Y73E7A.1, ZTF-6

Targeted by: BCL-11, CEH-14, CEH-18, CEH-31, CEH-34, CEH-39, CEH-48, CND-1, COG-1, DVE-1, ETS-4, HAM-2, HLH-30, HMG-4, LSY-2, MEP-1, MLS-2, NFYA-1, PHA-4, PROS-1, REF-2, SPTF-1, TBX-2, UNC-120, UNC-42, UNC-55, ZIP-8, ALY-2, BLMP-1, C16A3.4, CEH-82, DPL-1, DSC-1, EFL-1, ELT-3, FKH-8, FOS-1, IRX-1, MDL-1, MEF-2, NHR-85, PAX-3, RNT-1, SKN-1, SWSN-7, UNC-130, UNC-86, VAB-15, ZTF-11

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: ALY-1, ATHP-1, CEH-20, CEH-39, DPFF-1, EFL-1, EFL-3, ETS-5, HLH-2, HLH-30, HMG-20, K10B3.5, LIN-15B, LSY-2, MDL-1, MEP-1, MML-1, NFYA-1, NFYC-1, RCOR-1, SWSN-7, UNC-37, UNC-62, ATFS-1, CAMT-1, CEBP-1, CEH-5, CRH-2, DMD-5, DPL-1, F19F10.9, GMEB-1, HLH-1, HLH-11, LAG-1, MEF-2, NHR-10, NHR-23, NHR-49, NHR-85, SKN-1, SMA-2, TLP-1, Y73E7A.1

Targeted by: BCL-11, CEH-14, CEH-18, CEH-31, CEH-34, CEH-39, CEH-48, CND-1, COG-1, DVE-1, ETS-4, HAM-2, HLH-30, HMG-4, LSY-2, MEP-1, MLS-2, NFYA-1, PHA-4, PROS-1, REF-2, SPTF-1, TBX-2, UNC-120, UNC-42, UNC-55, ALY-2, BLMP-1, C16A3.4, CEH-82, DPL-1, DSC-1, EFL-1, ELT-3, FKH-8, FOS-1, IRX-1, MDL-1, MEF-2, NHR-85, PAX-3, RNT-1, SKN-1, SWSN-7, UNC-130, UNC-86, VAB-15, ZTF-11