HMG-4

WormBase ID: WBGene00001974

WormBase description: Is an ortholog of human SSRP1 (structure specific recognition protein 1). Is predicted to have histone binding activity and nucleosome binding activity. Is involved in pharynx development and regulation of embryonic development. Localizes to nucleus. Is expressed in several structures, including coelomocyte; head muscle; neurons; somatic cell; and somatic nervous system. Human ortholog(s) of this gene are implicated in mitochondrial DNA depletion syndrome 15.

Reporter verification: Verified by whole-genome sequencing
Primers used to verify fosmid reporter: nan

Strain name: SYS226

Cross: OP660 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs660 (hmg-4::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Transient-expression

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: BLMP-1, CAMT-1, CEBP-1, CEH-13, CEH-20, CEH-38, CEH-39, CEH-43, CES-2, CRH-2, DAF-19, DAF-3, DMD-5, DUXL-1, DVE-1, EFL-3, EGL-18, EGL-44, EGL-46, EGRH-1, ELT-6, ETS-5, FOS-1, GMEB-1, GMEB-2, HBL-1, HLH-1, HLH-2, HLH-30, K09A11.1, LAG-1, LIM-7, LIN-13, LIN-15B, MDL-1, MML-1, NHR-102, NHR-23, NHR-25, NHR-35, NHR-49, NHR-6, POP-1, SDZ-38, SEL-8, SOX-2, SWSN-7, SYD-9, UNC-120, UNC-3, UNC-37, UNC-62, Y55F3AM.14, Y75B8A.6, ZAG-1, ZFH-2, ZTF-11, ZTF-6

Targeted by: PHA-4

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: BLMP-1, CAMT-1, CEBP-1, CEH-13, CEH-20, CEH-39, CEH-43, CES-2, CRH-2, DAF-19, DMD-5, DUXL-1, DVE-1, EFL-3, EGL-44, EGL-46, ELT-6, ETS-5, GMEB-1, GMEB-2, HBL-1, HLH-1, HLH-2, HLH-30, LAG-1, LIN-13, LIN-15B, MDL-1, MML-1, NHR-23, NHR-25, NHR-35, NHR-49, POP-1, SOX-2, SVH-5, SWSN-7, SYD-9, UNC-120, UNC-37, UNC-62, ZAG-1, ZFH-2, ZTF-11

Targeted by: PHA-4