EYG-1

WormBase ID: WBGene00013147

WormBase description: Is an ortholog of several human genes including PAX2 (paired box 2); PROP1 (PROP paired-like homeobox 1); and RHOXF1 (Rhox homeobox family member 1). Is predicted to have DNA binding activity. Is expressed in head and pharynx. Human ortholog(s) of this gene are implicated in several diseases, including Leri-Weill dyschondrosteosis; diabetes mellitus (multiple); and eye disease (multiple).

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-CCATCTCCCAATGAACGAGC-3'

Strain name: SYS275

Cross: OP441 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs441 (eyg-1::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Lineage-specific, Pharynx-specific

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): CEH-2, DMD-5, CEH-34, CEH-16, CEH-6, Y48G1C.6, CEH-27, CEH-45, SEM-2, PHA-4, M03D4.4, ZAG-1, CES-2, CEH-36, CEBP-1


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: DMD-5, DAF-19, ETS-5, HBL-1, K09A11.1, LAG-1, LIM-7, MDL-1, MEP-1, NHR-102, SWSN-7, ZTF-6

Targeted by: PHA-4, ZIP-8

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: DMD-5, DAF-19, ETS-5, LAG-1, MDL-1, MEP-1, SWSN-7

Targeted by: PHA-4, ZIP-8