FKH-6

WormBase ID: WBGene00001438

WormBase description: Is an ortholog of human FOXE3 (forkhead box E3). Exhibits sequence-specific DNA binding activity. Is involved in male germ-line sex determination and male gonad development. Is expressed in gonadal sheath cell; male gonad; somatic gonad precursor; spermatheca; and in male. Human ortholog(s) of this gene are implicated in Bamforth-Lazarus syndrome; lens disease (multiple); and persistent fetal circulation syndrome.

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-CCTGGGATTTCAAGTACAAC-3'

Strain name: SYS574

Cross: OP78 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs78 (fkh-6::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Not expressed

Lineage expression pattern

350 stage

600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): NA


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: CEH-39, CEH-43, DAF-19, DMD-5, EGL-18, EGL-44, EGRH-1, ETS-5, HBL-1, K09A11.1, LIM-7, NHR-102, RCOR-1, SWSN-7, TBX-2, UNC-37, ZTF-11

Targeted by: NA

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: CEH-39, CEH-43, DAF-19, DMD-5, EGL-44, ETS-5, RCOR-1, SWSN-7, TBX-2, UNC-37, ZTF-11

Targeted by: NA