WormBase ID: WBGene00004771 WormBase description: Is an ortholog of several human genes including SOX11 (SRY-box transcription factor 11); SOX12 (SRY-box transcription factor 12); and SOX4 (SRY-box transcription factor 4). Is predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Is involved in several processes, including cell fate specification; positive regulation of oviposition; and positive regulation of vulval development. Localizes to nucleus. Is expressed in several structures, including E lineage cell; M.v nucleus; RMH; body wall muscle cell from M lineage; and neuroblasts. Human ortholog(s) of this gene are implicated in several diseases, including 46 XY gonadal dysgenesis; PCWH syndrome; and Waardenburg's syndrome (multiple). |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS227 Cross: OP701 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs701 (sem-2::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Lineage-specific, Anterior-biased, Transient-expression |
Lineage expression pattern 350 stage     |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): CEH-45, CEH-30, REF-2, TAB-1, CEH-31, EYG-1, CEH-41, CEH-32, HLH-30, SOX-2, CEH-34, LIM-7, TBX-38, MLS-2, LIN-32, ELT-6, PHA-4, CEH-27, EFL-3, CEH-83, ZIP-8 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: LIM-7, EFL-3, AST-1, CEH-38, CEH-44, DAF-19, DMD-5, ETS-5, K09A11.1, LAG-1, NHR-102, POP-1, SEL-8, UNC-62 |
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Targeting: DAF-19, DMD-5, ETS-5, LAG-1, POP-1, UNC-62 Targeted by: BLMP-1 |
