WormBase ID: WBGene00006743 WormBase description: Is an ortholog of human EBF3 (EBF transcription factor 3). Exhibits RNA polymerase II regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and identical protein binding activity. Is involved in several processes, including dauer larval development; positive regulation of transcription by RNA polymerase II; and regulation of neuron projection development. Localizes to nucleus. Colocalizes with nuclear chromatin. Is expressed in ABalappaap; ABalappaapp; and neurons. |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS70 Cross: OP578 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs578 (unc-3::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Anterior-biased, Neuronal-specific |
Lineage expression pattern 350 stage      |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): LIN-11, NOB-1, ZAG-1, VAB-15, HLH-14, CEH-6, EGL-46, CEH-48, CND-1, CEH-13, VAB-3, PHP-3, UNC-30, ATF-7, CEH-20, UNC-62, EGL-44, NHR-25, SOX-2, EFL-3, HLH-2, ZTF-11, ELT-6 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: UNC-62, CRH-2, EGRH-1, ELT-1, ETS-5, K09A11.1, LIM-7, MDL-1, NHR-102, RCOR-1, ZFH-2 Targeted by: CND-1, UNC-62, CEH-31, HMG-4, LSY-2, NFYA-1, UNC-42, UNC-55, BLMP-1, DSC-1, ELT-3, MDL-1, NHR-85, SKN-1, TBX-2 |
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Targeting: UNC-62, CRH-2, ETS-5, MDL-1, RCOR-1 Targeted by: NA |
