WormBase ID: WBGene00044330 WormBase description: Is an ortholog of human ALX1 (ALX homeobox 1). Exhibits RNA polymerase II regulatory region sequence-specific DNA binding activity. Localizes to nucleus. Is expressed in several structures, including anterior hypodermis; neurons; pseudocoelom; socket cell; and somatic nervous system. Human ortholog(s) of this gene are implicated in several diseases, including WAGR syndrome; diabetes mellitus (multiple); and eye disease (multiple). |
Reporter verification: Verified by PCR and sequencing |
Strain name: RW10757 Strain genotype: unc-119 (ed3) III; itIs37 (pie-1p::mCherry::H2B::pie-1 3'UTR + unc-119(+)); stIs10116 (his-72p::his-24::mCherry::let-858 3'UTR + unc-119(+)); stIs10757 (alr-1::TGF(10A2)::GFP::TY1::3xFLAG) |
Expression pattern: Lineage-specific, Transient-expression |
Lineage expression pattern 350 stage ![]() ![]() |
600 stage ![]() |
3D expression pattern ![]() 4-cells ![]() 8-cells ![]() 15-cells ![]() 28-cells ![]() ~50-cells ![]() ~100-cells ![]() ~200-cells ![]() ~350-cells ![]() ~500-cells ![]() ~600-cells ![]() 600-cells ![]() bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): UNC-30, CEH-8, LET-381, TBX-7, UNC-39, CEH-51, UNC-130, VAB-3, CEH-31, Y56A3A.28, FKH-2, HLH-30, CEH-32, ZIP-8, F23B12.7 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeted by: CEH-34, ELT-1, ELT-2, ETS-7, REF-2, UNC-30, UNC-130, BLMP-1, DSC-1, EGL-13, ELT-3, FKH-10, LSY-2 |
Targeted by: CEH-34, ELT-1, REF-2, BLMP-1, EGL-13, ELT-3, FKH-10 |