WormBase ID: WBGene00000438 WormBase description: Is an ortholog of human LHX3 (LIM homeobox 3) and LHX4 (LIM homeobox 4). Exhibits RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in neuron development; positive regulation of transcription by RNA polymerase II; and thermosensory behavior. Localizes to nucleus. Is expressed in several structures, including hypodermal cell; neurons; somatic nervous system; spermatheca; and tail. Human ortholog(s) of this gene are implicated in several diseases, including congenital ptosis; myopathy (multiple); and nail-patella syndrome. |
Reporter verification: Verified by PCR and sequencing |
Strain name: SYS1053 Cross: OP73 x JIM113 Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs73 (ceh-14::TY1::EGFP::3xFLAG + unc-119(+)) |
Expression pattern: Expressed after bean stage (based on Reilly et al. 2020; PMID: 32814896) |
Lineage expression pattern 350 stage   |
600 stage  |
3D expression pattern  4-cells  8-cells  15-cells  28-cells  ~50-cells  ~100-cells  ~200-cells  ~350-cells  ~500-cells  ~600-cells  600-cells  bean-stage |
Inferred TF relationships Based on expression similarity (strong, medium, weak): NHR-67, TAB-1, CEH-48, ZAG-1 Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined) Targeting: CEH-48, ZAG-1, CAMT-1, CEBP-1, CEH-38, CEH-39, CEH-44, COG-1, DAF-12, DAF-19, DAF-3, DMD-5, EFL-1, EGL-18, EGL-5, EGRH-1, ETS-5, GMEB-1, HLH-11, K09A11.1, LAG-1, LIM-7, LIN-13, MDL-1, MEF-2, NHR-10, NHR-102, NHR-49, NOB-1, RCOR-1, SDZ-38, SEL-8, SEM-4, SKN-1, SYD-9, UNC-37, UNC-62, Y55F3AM.14, Y73E7A.1, ZFH-2, ZTF-6 |
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Targeting: CEH-48, CAMT-1, CEBP-1, CEH-39, COG-1, DAF-19, DAF-3, DMD-5, EFL-1, EGL-5, ETS-5, GMEB-1, HLH-30, LAG-1, LIN-13, MDL-1, MEF-2, NHR-10, NHR-49, NOB-1, RCOR-1, SKN-1, SVH-5, UNC-37, UNC-62, Y73E7A.1, ZFH-2 |
