TBX-9

WormBase ID: WBGene00006546

WormBase description: Is an ortholog of human EOMES (eomesodermin) and TBR1 (T-box brain transcription factor 1). Exhibits RNA polymerase II regulatory region sequence-specific DNA binding activity. Is involved in embryonic body morphogenesis. Localizes to nucleus. Is expressed in several structures, including ABarpa; Eal; Ear; Epl; and Epr. Human ortholog(s) of this gene are implicated in adrenocorticotropic hormone deficiency; atrial heart septal defect 4; and dysostosis (multiple).

Reporter verification: Verified by PCR and sequencing
Primers used to verify fosmid reporter: 5'-GCGTCCCACAATCCTCAAAC-3'

Strain name: SYS229

Cross: OP617 x JIM113

Strain genotype: ujIs113 (pie-1p::mCherry::H2B; nhr-2p::mCherry::his-24::let858 3'UTR; unc-119(+)) II; wgIs617 (tbx-9::TY1::EGFP::3xFLAG + unc-119(+))

Expression pattern: Lineage-specific, Posterior-biased, Tissue-specific (Muscle and Intestine), Transient-expression

Lineage expression pattern

350 stage


600 stage

3D expression pattern

4-cells

8-cells

15-cells

28-cells

~50-cells

~100-cells

~200-cells

~350-cells

~500-cells

~600-cells

600-cells

bean-stage

Inferred TF relationships

Based on expression similarity (strong, medium, weak): ELT-3, END-3, TBX-8, END-1, HND-1, ELT-7, NHR-102, ELT-1, HLH-1, NHR-12, UNC-120, DVE-1, PAL-1, VAB-7, TBX-38, NHR-23, CEH-13, HMBX-1, UNC-62, CEH-20, M03D4.4, NHR-25, TBX-11, CEH-39, CEH-74


Based on ChIP-seq (directly from ModERN database, targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA

Based on reannotated ChIP-seq (peaks are assigned to a target if it is located within 2 kb relative to the transcription start site; targets from L1 stage ChIP-seq data are underlined)

Targeting: no-data

Targeted by: NA